VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Do C1q or IgM nephropathies predict disease severity in children with minimal change nephrotic syndrome?
    Vintar Spreitzer, Mateja ...
    Background It has been suggested that C1q and immunoglobulin M (IgM) nephropathy are variants of minimal change nephrotic syndrome (MCNS). Many researchers believe that these two conditions signify a ... worse prognosis for children with MCNS in comparison with immunofluorescence (IF)-negative MCNS. The aim of our study was to determine the prognostic significance of C1q nephropathy and IgM nephropathy in children with MCNS. Methods Fifty-five children with MCNS who had been biopsied over the course of 24 years at our institution were retrospectively categorized into three groups on the basis of IF microscopy findings: IF-negative MCNS (29/55 patients), MCNS with IgM nephropathy (19/55 patients), and MCNS with C1q nephropathy (7/55 patients). Clinical characteristics at disease presentation, clinical course, and renal outcome were compared between groups during the median follow-up period of 16.9 years (minimum 1.0, maximum 31.1 years). Results No statistically significant differences in clinical characteristics at disease presentation, clinical course, and renal outcome were found. Children with IgM nephropathy, C1q nephropathy, and IF-negative MCNS were clinically indistinguishable. Conclusions We concluded that C1q or IgM nephropathy variants do not seem to signify a worse prognosis in children with MCNS in comparison with IF-negative MCNS.
    Vir: Pediatric nephrology. - ISSN 0931-041X (Vol. 29, no. 1, Jan. 2014, str. 67-74)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 31820761
    DOI

vir: Pediatric nephrology. - ISSN 0931-041X (Vol. 29, no. 1, Jan. 2014, str. 67-74)
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