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  • Serum amyloid A is a marker for pulmonary involvement in systemic sclerosis [Elektronski vir]
    Lakota, Katja ...
    Inflammation in systemic sclerosis (SSc) is a prominent, but incompletely characterized fea- ture in early stages of the disease. The goal of these studies was to determine the circulat- ing levels, ... clinical correlates and biological effects of the acute phase protein serum amyloid A (SAA), a marker of inflammation, in patients with SSc. Circulating levels of SAA were determined by multiplex assays in serum from 129 SSc patients and 98 healthy con- trols. Correlations between SAA levels and clinical and laboratory features of disease were analyzed. The effects of SAA on human pulmonary fibroblasts were studied ex vivo. Elevat- ed levels of SAA were found in 25% of SSc patients, with the highest levels in those with early-stage disease and diffuse cutaneous involvement. Significant negative correlations of SAA were found with forced vital capacity and diffusion capacity for carbon monoxide. Pa- tients with elevated SAA had greater dyspnea and more frequent interstitial lung disease, and had worse scores on patient-reported outcome measures. Incubation with recombinant SAA induced dose-dependent stimulation of IL-6 and IL-8 in normal lung fibroblasts in cul- ture. Serum levels of the inflammatory marker SAA are elevated in patients with early dif- fuse cutaneous SSc, and correlate with pulmonary involvement. In lung fibroblasts, SAA acts as a direct stimulus for increased cytokine production. These findings suggest that sys- temic inflammation in SSc may be linked to lung involvement and SAA could serve as a po- tential biomarker for this complication.
    Vir: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 10, iss. 1, Jan. 2015)
    Vrsta gradiva - e-članek
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 31899609

    Povezava(-e):

    http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110820#sec002
    DOI

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