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  • Impaired [alpha]GDI function in the X-linked intellectual disability : the impact on astroglia vesicle dynamics
    Potokar, Maja, 1973- ...
    X-linked non-syndromic intellectual disability (XLID) is a common mental disorder recognized by cognitive and behavioral deficits. Mutations in the brain-specific [alpha]GDI, shown to alter a subset ... of RAB GTPases redistribution in cells, are linked to XLID, likely via changes in vesicle traffic in neurons. Here, we show directly that isolated XLID mice astrocytes, devoid of pathologic tissue environment, exhibit vesicle mobility deficits. Contrary to previous studies, we show that astrocytes express two GDI proteins. The siRNA-mediated suppression of expression of [alpha]GDI especially affected vesicle dynamics. A similar defect was recorded in astrocytes from the Gdi1 -/Y mouse model of XLID and in astrocytes with recombinant mutated human XLID [alpha]GDI. Endolysosomal vesicles studied here are involved in the release of gliosignaling molecules as well as in regulating membrane receptor density; thus, the observed changes in astrocytic vesicle mobility may, over the long time-course, profoundly affect signaling capacity of these cells, which optimize neural activity.
    Vir: Molecular neurobiology. - ISSN 0893-7648 (Vol. 54, iss. 4, May 2017, str. 2458-2468)
    Vrsta gradiva - članek, sestavni del
    Leto - 2017
    Jezik - angleški
    COBISS.SI-ID - 32572377

    Povezava(-e):

    http://link.springer.com/article/10.1007%2Fs12035-016-9834-1
    DOI

vir: Molecular neurobiology. - ISSN 0893-7648 (Vol. 54, iss. 4, May 2017, str. 2458-2468)
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