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  • Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
    Filbin, Mariella G. ...
    Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and ... cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like cells exhibit greater proliferation and tumor-propagating potential than their more differentiated counterparts and are at least in part sustained by PDGFRA signaling. Our study characterizes oncogenic and developmental programs in H3K27M-glioma at single-cell resolution and across genetic subclones, suggesting potential therapeutic targets in this disease.
    Vir: Science. - ISSN 0036-8075 (Vol. 360, iss. 6386, Apr. 2018, str. 331-335)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2018
    Jezik - angleški
    COBISS.SI-ID - 33745625

    Povezava(-e):

    http://science.sciencemag.org/content/360/6386/331.long
    DOI

vir: Science. - ISSN 0036-8075 (Vol. 360, iss. 6386, Apr. 2018, str. 331-335)
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