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  • Controlled release of ciprofloxacin from core - shell nanofibers with monolithic or blended core
    Zupančič, Špela, farmacevtka ...
    Sustained controlled drug release is one of the prominent contributions for more successful treatment outcomes in the case of several diseases. However, the incorporation of hydrophilic drugs into ... nanofibers, a promising novel delivery system, and achieving a long-term sustained release still pose a challenging task. In this work we demonstrated a robust method of avoiding burst release of drugs and achieving a sustained drug release from 2 to 4 weeks using core-shell nanofibers with poly(methylmethacrylate) (PMMA) shell and monolithic poly(vinyl alcohol) (PVA) or a novel type of core-shell nanofibers with blended (PVA and PMMA) core loaded with ciprofloxacin hydrochloride (CIP). It is also shown that for core-shell nanofibers with monolithic core, drug release can be manipulated by varying flow rate of the core PVA solution, whereas for core-shell nanofibers with blended core drug release can be manipulated by varying the ratios between PMMA and PVA in the core. During coaxial electrospinning, when the solvent from the core evaporates in concert with the solvent from the shell, the inter-connected pores spanning the core and the shell are formed. The release process is found to be desorption-limited and agrees with the two-stage desorption model. Ciprofloxacin-loaded nanofiber mats developed in the present work could be potentially used as local drug delivery systems for treatment of several medical conditions, including periodontal disease, skin, bone and joint infections.
    Vir: Molecular pharmaceutics. - ISSN 1543-8384 (Vol. 13, iss. 4, 2016, str. 1393-1404)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2016
    Jezik - angleški
    COBISS.SI-ID - 4035953

    Povezava(-e):

    http://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.6b00039
    http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.6b00039
    DOI

vir: Molecular pharmaceutics. - ISSN 1543-8384 (Vol. 13, iss. 4, 2016, str. 1393-1404)
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