VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Histamine N-methyltransferase Thr105Ile polymorphism is associated with Parkinson's disease
    Palada, Vinko ...
    Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus ... we tested the possible association of a Thr105Ile functional polymorphismin HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls(Ž(2) = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicatethat lower HNMT activity plays a role in the pathogenesis of PD.
    Vir: Neurobiology of aging. - ISSN 0197-4580 (Vol. 33, no. 4, apr. 2012, str. 836.e1-836.e3)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 685996

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0197458011002326
    DOI

vir: Neurobiology of aging. - ISSN 0197-4580 (Vol. 33, no. 4, apr. 2012, str. 836.e1-836.e3)
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