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  • Interaction between equally charged membrane surfaces mediated by positively and negatively charged macro-ions
    Perutková, Šárka ...
    In biological systems, charged membrane surfaces are surrounded by charged molecules such as electrolyte ions and proteins. Our recent experiments in thesystems of giant phospholipid vesicles ... indicated that some of the blood plasma proteins (macro-ions) may promote adhesion between equally charged membrane surfaces. In this work, theory was put forward to describe an IgG antibody-mediated attractive interaction between negatively charged membrane surfaces which was observed in experiments on giant phospholipid vesicles withcardiolipin-containing membranes. The attractive interactions between negatively charged membrane surfaces in the presence of negatively and positively charged spherical macro-ions are explained using functional densitytheory and Monte Carlo simulations. Both, the rigorous solution of the variational problem within the functional density theory and the Monte Carlo simulations show that spatial and orientational ordering of macro-ions may give rise to an attractive interaction between negatively charged membrane surfaces. It is also shown that the distinctive spatial distribution of the charge within the macro-ions (proteins) is essential in this process.
    Vir: The journal of membrane biology. - ISSN 0022-2631 (Vol. 236, no. 1, Jul. 2010, str. 43-53)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 7871060

vir: The journal of membrane biology. - ISSN 0022-2631 (Vol. 236, no. 1, Jul. 2010, str. 43-53)
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