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  • Langerhans cells in human papillomaviruses types 6/11 associated laryngeal papillomas
    Ferluga, Dušan, 1934- ...
    Some studies have shown a reduced density of Langerhans cells (LCs) within epith on a correlation between HPV types 6/11 infection and LCs have been missing. To solve this problem, we analysed 24 ... biopsy specimens of laryngeal papillomas, selected randomly, 20 multiple and 4 solitary. The presence of HPV6 and 11 was proven by polymerase chain reaction (PCR) using 2 different sets of primers in 23 biopsy specimens. Abnormalities of the covering stratified squamous epithelium were graded according to the Kambič-Gale classification.. LCs were immunohistochemically labelled with 2 different antibodies, CD1a and S100. Quantitative analysis was performed to determine the density of LC per mm/2 in different grades of epithelial abnormalities covering laryngeal papillomas. Although no statistically significant differences in the mean number of LCs per mm/2 of the cross-sectioned epithelium covering laryngeal papillomas were observed comparing simple, abnormal and atypical hyperplasmber of LCs per mm/2 in laryngeal papillomas associated with HPV types 6/11 infection substantially exceeded that of the vocal cord surface epithelium in patients with chronic laryngitis.
    Vir: Acta oto-laryngologica. Supplementum. - ISSN 0365-5237 (Suppl. 527, 1997, str. 87-91)
    Vrsta gradiva - članek, sestavni del
    Leto - 1997
    Jezik - angleški
    COBISS.SI-ID - 81369

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