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Possible role of autoimmunity in patients with premature ovarian insufficiency
Košir-Pogačnik, Renata, dr. med. ...
Background: To evaluate the involvement of immune abnormality in patients with idiopathicpremature ovarian insufficiency (POI). In addition to the known etiology, autoimmunedisorders may be a ...pathologic mechanism for POI.Materials and Methods: Our study was a prospective controlled trial. Twenty womenwith POI, reasons other than autoimmune excluded, were enrolled in this study.The control group consisted of 17 healthy women. In both groups, family and personalhistory were taken and the levels of follicle stimulating hormone, luteinizinghormone, thyroid-stimulating hormone, prolactin, anti-Müllerian hormone, inhibinB, antithyroglobulin and antithyroid peroxidase antibodies were determined. Antiovarianantibodies and subpopulations of peripheral blood T-lymhocytes were alsodetermined.Results: Participants in the study group exhibited hypergonadotropichypogonadism,while high levels of follicle stimulating hormone and low levels of inhibin B and anti-Müllerian hormone were observed. In 16 (80%) patients, POI was associated in theirpersonal and familial history with another autoimmune disease. Fifty percent of patientspresented highly elevated antithyroid antibodies. The lymphocyte subset, especially Bcells, was significantly higher (p=0.014), and peripheral regulatory lymphocytes CD25+high were significantly lower (p=0.015) in the study group than in the control group. Antiovarianantibodies were detected in 20% of patients with POI.Conclusion: We presume that the presence of anti-ovarian antibodies together with abnormalitiesof cellular immunity may in some cases potentially represent the involvementof an autoimmune mechanism in idiopathic POI.
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